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compounds 11a and 11b  (Janssen)

 
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    Structured Review

    Janssen compounds 11a and 11b
    Compounds 11a And 11b, supplied by Janssen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compounds 11a and 11b/product/Janssen
    Average 90 stars, based on 1 article reviews
    compounds 11a and 11b - by Bioz Stars, 2026-05
    90/100 stars

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    compounds 11a , 11b , 11d , 11e , and 11f  (Muegge GmbH)
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    Muegge GmbH compounds 11a , 11b , 11d , 11e , and 11f
    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / <t>11f</t> : R 1 = C 5 H 11 , R 2 = H).
    Compounds 11a , 11b , 11d , 11e , And 11f, supplied by Muegge GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compounds 11a , 11b , 11d , 11e , and 11f/product/Muegge GmbH
    Average 90 stars, based on 1 article reviews
    compounds 11a , 11b , 11d , 11e , and 11f - by Bioz Stars, 2026-05
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    authentic standards of model compounds 11a and 11b  (Tokyo Chemical Industry)
    90
    Tokyo Chemical Industry authentic standards of model compounds 11a and 11b
    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / <t>11f</t> : R 1 = C 5 H 11 , R 2 = H).
    Authentic Standards Of Model Compounds 11a And 11b, supplied by Tokyo Chemical Industry, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/authentic standards of model compounds 11a and 11b/product/Tokyo Chemical Industry
    Average 90 stars, based on 1 article reviews
    authentic standards of model compounds 11a and 11b - by Bioz Stars, 2026-05
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    compounds 11a and 11b  (Janssen)
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    Janssen compounds 11a and 11b
    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / <t>11f</t> : R 1 = C 5 H 11 , R 2 = H).
    Compounds 11a And 11b, supplied by Janssen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compounds 11a and 11b/product/Janssen
    Average 90 stars, based on 1 article reviews
    compounds 11a and 11b - by Bioz Stars, 2026-05
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    compounds 7, 8, 11a, 11b, 11d, 12a-d, 17a-d, 19, 20, and 22  (Pfizer Inc)
    90
    Pfizer Inc compounds 7, 8, 11a, 11b, 11d, 12a-d, 17a-d, 19, 20, and 22
    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / <t>11f</t> : R 1 = C 5 H 11 , R 2 = H).
    Compounds 7, 8, 11a, 11b, 11d, 12a D, 17a D, 19, 20, And 22, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compounds 7, 8, 11a, 11b, 11d, 12a-d, 17a-d, 19, 20, and 22/product/Pfizer Inc
    Average 90 stars, based on 1 article reviews
    compounds 7, 8, 11a, 11b, 11d, 12a-d, 17a-d, 19, 20, and 22 - by Bioz Stars, 2026-05
    90/100 stars
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    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / 11f : R 1 = C 5 H 11 , R 2 = H).

    Journal: International Journal of Molecular Sciences

    Article Title: Naphthoquinone-Quinolone Hybrids with Antitumor Effects on Breast Cancer Cell Lines—From the Synthesis to 3D-Cell Culture Effects

    doi: 10.3390/ijms25126490

    Figure Lengend Snippet: Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / 11f : R 1 = C 5 H 11 , R 2 = H).

    Article Snippet: Additionally, compounds 11a , 11b , 11d , 11e , and 11f exhibited zero violations of the drug-likeness rules of Lipinski, Ghose, Veber, Egan, and Muegge.

    Techniques: Reflux

    IC 50 values and selectivity indices (SI) of 1,4-naphthoquinone, compounds 11a–f , and doxorubicin.

    Journal: International Journal of Molecular Sciences

    Article Title: Naphthoquinone-Quinolone Hybrids with Antitumor Effects on Breast Cancer Cell Lines—From the Synthesis to 3D-Cell Culture Effects

    doi: 10.3390/ijms25126490

    Figure Lengend Snippet: IC 50 values and selectivity indices (SI) of 1,4-naphthoquinone, compounds 11a–f , and doxorubicin.

    Article Snippet: Additionally, compounds 11a , 11b , 11d , 11e , and 11f exhibited zero violations of the drug-likeness rules of Lipinski, Ghose, Veber, Egan, and Muegge.

    Techniques:

    Physicochemical parameter values for compounds 11a–f using Swiss ADME server.

    Journal: International Journal of Molecular Sciences

    Article Title: Naphthoquinone-Quinolone Hybrids with Antitumor Effects on Breast Cancer Cell Lines—From the Synthesis to 3D-Cell Culture Effects

    doi: 10.3390/ijms25126490

    Figure Lengend Snippet: Physicochemical parameter values for compounds 11a–f using Swiss ADME server.

    Article Snippet: Additionally, compounds 11a , 11b , 11d , 11e , and 11f exhibited zero violations of the drug-likeness rules of Lipinski, Ghose, Veber, Egan, and Muegge.

    Techniques: